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It is dropped, however, by some superiors, when referring to one's in-group, or in formal writing, and is never used to refer to oneself, except for dramatic effect, or some exceptional cases.

The series was initially published in Shōnen Sunday from the late 1970s through the early 1980s, and later returned at the end of the decade retitled as "Heisei-ban Makoto-chan".

The series follows the odd life of kindergartener Makoto Sawada and his family.

Makoto gets into all sorts of toilet and adult humor.

More recent MRI studies have reported age-related regional decreases in cerebral volume.

The brain is very complex, and is composed of many different areas and types of tissue, or matter.

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The Centor score is a well calibrated CPR for estimating the probability of GABHS pharyngitis.He sometimes dresses in his mother's and sister's clothing, and often has a long strand of mucus dangling from his nose.An animated film adaptation of the manga directed by Tsutomu Shibayama titled Makoto-chan was released in Japan on July 26, 1980 where it was distributed by Toho.Stratifying patients with a sore throat into the probability of having an underlying bacterial or viral cause may be helpful in targeting antibiotic treatment.We sought to assess the diagnostic accuracy of signs and symptoms and validate a clinical prediction rule (CPR), the Centor score, for predicting group A β-haemolytic streptococcal (GABHS) pharyngitis in adults ( A systematic literature search was performed up to July 2010. uses cookies to improve performance by remembering your session ID when you navigate from page to page.

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